The funding will support research grants to two early-career dementia researchers at the Washington University School of Medicine in St. Louis: Andrea Soranno, who is studying variations in the APOE gene most closely associated with risk for developing the disease, and Nelly Joseph-Mathurin, who is studying variations in the genes that cause familial younger-onset Alzheimer's. The grant also will support two clinical studies — one by WUSTL's Dominantly Inherited Alzheimer Network Trials Unit designed to test multiple experimental Alzheimer's treatments, and another at the University of Southern California that will explore vascular contributions to dementia in APOE4 carriers.
The firm also is supporting the Alzheimer's Association's U.S. POINTER Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk, a two-year, community-based trial aimed at evaluating the effectiveness of lifestyle modifications such as nutritional guidance and increased physical exercise in Americans who are believed to be at increased risk of memory decline and dementia.
"Groundbreaking ideas start early in a scientist's career. It is precisely at this point in their career that we must support scientists to attract and retain the best minds to our cause, and to create a vibrant research community," said Alzheimer's Association chief science officer Maria C. Carrillo "At any given moment, the Alzheimer's Association is fueling research across the globe. Partnerships like the one we have with Edward Jones enable us to test new ideas and build a robust research pipeline, which generates hope for potential new treatments."