The Pacific Neuroscience Institute Brain Health Center (PNI) at Providence Saint John's Health Center in Los Angeles has announced a $40 million gift from Will and Cary Singleton in support of efforts to develop novel and effective treatments for Alzheimer's disease and related memory and cognition disorders.
The gift will support research at PNI, where clinicians, in collaboration with the Institute of Systems Biology, are conducting a clinical trial to assess the impact of a cognitive fitness regimen for patients with early-stage Alzheimer's disease. Researchers hope to improve early detection and the profiling of the "at-risk" population using a combination of state-of-the-art neuroimaging, genomic data, and blood biomarkers while refining targeted lifestyle interventions to slow or even reverse cognitive decline. They also will assess the impact of novel interventions such as stem cells and repurposed drugs for patients who already have advanced dementia. Given the likely long-term impacts of the COVID-19 pandemic, the team also aims to further optimize telehealth platforms and remote-care models for dementia patients, their family members, and caregivers.
"The Singleton gift is the largest single donation we've ever received and is a testament to the caliber of research, clinical care, and medical talent that resides on our campus," said Saint John's Health Center Foundation president and CEO Bob Klein. "The Singleton family has been supportive of Saint John's for generations now....We are immensely grateful for this transformative gift."
"PNI and Saint John's Health Center have very innovative programs," said Will Singleton, who co-founded the Singleton Foundation for Financial Literacy with his wife. "They're able to move quickly with clinical trials, attract top-notch talent, and they're collaborative. We're confident that this investment will produce results in areas of medical research and treatment that to date have proven difficult to solve."