The Chan Zuckerberg Initiative is inviting applications for projects dedicated to single-cell analysis of inflammation.
Inflammation is a feature of many diseases and a cross-cutting area of biomedicine. Inflammation mediates the response to chronic and acute tissue injury and infection, driving homeostasis and tissue repair. It is also a driver of fibrosis, cardiovascular disease, inflammatory bowel disease, arthritis, neurodegeneration, adverse events associated with immunotherapies, and many other maladaptive processes. Mapping inflammation in diverse tissues therefore is a path with potential for understanding, diagnosing, and treating many different diseases.
To that end, CZI is inviting applications for pilot projects focused on the role of inflammation in maintaining health and triggering disease. The program seeks to support new teams comprising two or three principal investigators with different areas of expertise who can advance interdisciplinary analysis of inflammation. Grants of up to $175,000 over two years will be awarded in support of collaborate projects aimed at identifying principles underlying tissue homeostasis and inflammation at the single-cell level, with a focus on the mechanisms of inflammation at the cellular level, including its dynamics and resolution, its molecular drivers, and the effects of genetic and environmental risk factors on relevant cellular properties and interactions. Successful applications will bring together researchers in different experimental, computational, or medical domains.
Applications are encouraged from researchers in disciplines outside biomedicine who bring new technology, resources, or frameworks to the study of inflammation; groups of investigators who have not previously worked together; women, underrepresented minorities, and members of underserved populations; and early-career investigators (defined as principal investigators who have been in an independent faculty role for less than six years at the time of application).
To be eligible, applicants must hold a PhD, MD, or equivalent degree and must have an academic appointment and be in an independent faculty position or equivalent at an accredited college, university, medical school, or other research facility. Applications may be submitted by domestic and foreign nonprofit organizations; public and private institutions such as colleges, universities, hospitals, laboratories, and units of state and local government; and eligible agencies of the federal government.
See the Chan Zuckerberg Initiative website for complete program guidelines and application instructions.