Grants of up to $227,000 a year for up to three years will be awarded to support investigators who are actively conducting research directly related to improving the life expectancy and quality of life of pediatric heart transplant recipients.
Priorities include evidence-based strategies for improving treatment adherence; early and accurate identification of acute cellular and antibody-mediated rejection and cardiac allograft vasculopathy, including the development of accurate non-invasive methods and strategies for surveillance; studies on the causes, prevention, and treatment of cardiac allograft vasculopathy; strategies to improve the viability of donor hearts; and the development of novel immunotherapies by the identification of novel targets, by improving the side-effect profiles of immunotherapies, and/or by improving methods for monitoring the level of immunosuppression. Applications for the development of new technologies that would address any of these priority areas will also be considered. Additional consideration will be given to applications that include clinical research or applications that include feasible clinical translations(s).
Proposals are encouraged from all basic science disciplines as well as epidemiological, behavioral, community and clinical investigations that bear on pediatric heart transplantation. Awards are open to professionals in academic disciplines (biology, chemistry, engineering, mathematics, technology, immunology, physiology, etc.) and health-related professions (physicians, nurses, advanced practice nurses, pharmacists, dentists, physical and occupational therapists, statisticians, nutritionists, behavioral scientists, health attorneys, biomedical engineers, psychologists, etc.). Applications are strongly encouraged from women, candidates from racial and ethnic groups underrepresented in the sciences, those who have experienced diverse and non-traditional career trajectories, and those whose research has previously been outside of cardiovascular science.
Applications must be submitted jointly by at least two co-principal investigators but no more than four. At least one co-PI must work in research directly related to pediatric heart transplantation, at least one must work in a different discipline (e.g., engineering, computer science, chemistry, mathematics, psychology, health law, genomics/genetics, etc.) and/or not have a prior focus in clinical pediatric heart transplantation, and at least one must be early- (assistant professor or equivalent) or mid-career (associate professor or equivalent).
Letters of Intent are due June 1. Upon review, selected applicants will be invited to submit a full proposal by September 1, 2020.
To be eligible, each co-PI must hold an MD, PhD, DO, DDS, DVM or equivalent post-baccalaureate terminal (highest-level) degree in his/her discipline.
See the American Heart Association website for complete program guidelines and application instructions.