Progeria Research Foundation Seeks Proposals for Research on Hutchinson-Gilford Progeria Syndrome

The Progeria Research Foundation is the only organization in the world dedicated to discovering treatments and the cure for progeria and its aging-related disorders. Progeria is a rare, fatal, "premature aging" disease caused by a mutant protein known as progerin. Affected children exhibit excessive atherosclerosis and die at an average age of 14 years due to heart attack or stroke.

To advance its mission, the organization is seeking proposals for research projects in all areas directly relevant to progeria. Priority will be given to research related to the discovery of biological markers of disease in HGPS that can be assessed in human and/or mouse samples; projects that explore biomarker relevance to disease process and/or change in markers with disease treatment; and the discovery and/or testing of candidate treatment compounds in both cell-based and mouse models of HGPS.

Grants will be awarded in three categories: Innovator Awards, Established Investigator Awards, and Specialty Awards.

1) Innovator Awards: The aim of the Innovator Award is to enable an investigator to embark on a new line of investigation and produce enough preliminary data for him/her to be competitive for longer-term funding by NIH and/or other agencies. Funding is for up to two years and up to $75,000 per year.

2) Established Investigator Awards: These awards are designed for advanced investigations in areas critical to the goals of PRF by senior investigators established either in the field of progeria or a field that can be directly applied to progeria. Funding is for up to three years and up to $100,000 per year.

3) Specialty Awards: Specialty awards are for smaller, more technology-driven projects (e.g., sequencing, screening potential drugs, obtaining cell lines, preparation of antibodies). Grant amounts range from between $5,000 to $50,000 and the length of the project is usually for a year or less. Funding amount and duration may be more for a project that addresses a need of great and immediate interest to the organization.

To be eligible, principal investigators must hold a postdoctoral position or beyond. PIs wishing to have a project performed by a postdoctoral associate must act as co-principal investigators. Grants only will be awarded to applicants affiliated with an institution with 501(c)(3) status (or the equivalent for foreign institutions).

For complete program guidelines and application instructions, see the Progeria Research Foundation website.

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