As health advances allow people to live longer, healthy aging has become an urgent frontier for research. The burden of age-related cognitive impairment — whether from Alzheimer's disease, vascular dysfunction, or other causes — is growing exponentially. To accelerate collaborative brain-aging research, the Paul G. Allen Frontiers Group and the American Heart Association/American Stroke Association are committing $43 million with additional partners to co-fund a new research initiative with the goal of shedding new light on how to better prevent, detect, and treat age-related cognitive impairment, including Alzheimer's disease.
The purpose of the American Heart Association/Allen Initiative in Brain Health and Cognitive Impairment is to discover and fund highly promising teams of investigators who can expand the frontiers of bioscience, pursuing creative, transformative ideas with the potential to move brain health and cognitive impairment science forward. The initiative will award up to $43 million over eight years to one or more highly inspiring and innovative integrated team(s) for large-scale integrated research that identifies novel, early, actionable, biological/mechanistic contributors to age-related cognitive impairment.
First-stage applicants should propose a scope of research that could be completed at a minimum level of $15 million or larger. Awardees will be invited to and expected to attend symposia, conferences, and other gatherings of American Heart Association and/or Paul G. Allen Frontiers Group researchers. These events offer time for cross-fertilization of frontier bioscience ideas and new collaborative opportunities.
To be eligible, team lead applicants are expected to be PhD and/or MD (or the equivalent); have a faculty appointment at an eligible nonprofit institution in the U.S. or an equivalent faculty position at a foreign University that meets foreign equivalency determinants for a nonprofit in the United States; demonstrate the ability to develop new tools and methods that support creative experimental approaches to questions, utilizing techniques from other disciplines, if appropriate; and demonstrate creativity in their scientific ideas and commitment to take risks on forward-looking concepts of major scientific impact. The initiative seeks and strongly encourages applications from women and members of minority groups that are underrepresented in biomedical sciences.
The AHA will begin accepting applications on May 21.
See the AHA website for complete program guidelines and proposal submission instructions.