PSC Partners Seeking a Cure is a nonprofit foundation whose mission is to provide education and support to patients with primary sclerosing cholangitis, their families, and their caregivers and to raise funds for research on the causes, treatments, and cures for PSC, an autoimmune disease that causes the bile ducts inside and outside the liver to become scarred, narrowed, and eventually blocked.
The foundation offers grants of up to $60,000 over two years in support of projects that address a novel, basic, or clinical research question related to PSC and closely allied diseases (such as inflammatory bowel diseases, ulcerative colitis, or Crohn's disease) as they relate to PSC.
Preference will be given to projects that have the potential to discover a cure for the disease and/or that identify novel therapies which may significantly delay time to liver transplantation, prevent disease recurrence following liver transplantation, and/or improve the quality of life of those with PSC.
The foundation recognizes that fundamental research is necessary to discover the environmental factors that may trigger the disease in genetically susceptible individuals and encourages research proposals aimed at identifying the gene-environment interactions contributing to disease initiation and progression. The foundation also is interested in funding research that explores PSC-related diseases (UC and Crohn’s disease) and the ways that they impact, enable, or perhaps cause PSC.
Research that will be complementary to the goals and objectives of the International PSC Study Group, including investigation of the functional roles of genes associated with susceptibility to and severity of PSC, is encouraged.
Other priority areas for research include the mechanisms of PSC pathogenesis and colorectal and cholangiocarcinoma carcinogenesis, as well as strategies for prevention. Projects focused on assessing and improving the quality of life of PSC patients are also encouraged, as are projects that address PSC in children and projects focused on assessing and improving the quality of life of PSC patients.
To be eligible, the applicant must be at an academic institution with an interest in pursuing PSC as an indication for treatment.
For complete program guidelines and application instructions, see the PSC Partners Seeking a Cure website.