PCORI Invites Applications for Improving Methods for Conducting Patient-Centered Outcomes Research

The Patient-Centered Outcomes Research Institute (PCORI) has issued a funding announcement for Improving Methods for Conducting Patient-Centered Outcomes Research.

Under this call, grants of up to 750,000 over three years will be awarded in support of projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by PCOR/CER studies. PCORI has identified the following areas of interest as programmatic priorities:

Methods Related to Ethical and Human Subjects Protections (HSP) Issues in PCOR/CER — Projects that address important ethical and HSP issues related to the conduct of PCOR/CER. Applications in this category must include an empirical component. PCORI will give preference to proposals that seek to develop or test new approaches rather than those that conduct primarily descriptive work.

Methods to Improve Study Design — Projects that foster improvements in the use of specific study designs to address PCOR/CER questions. Preference will be given to proposals that seek to evaluate the proposed methods using both simulations and data from real-world studies.

Methods to Support Data Research Networks — Projects that improve the quality of data and analyses for multi-site PCOR/CER using data research networks. PCORI will consider projects that focus on infrastructure development and/or capacity-building for specific platforms to be nonresponsive.

Methods to Improve the Use of Natural Language Processing — Projects that develop and evaluate natural language processing (NLP) and other related methods for leveraging free-text clinical information contained in electronic health records (EHRs) for PCOR/CER. PCORI will consider proposals that simply seek to apply NLP to a particular clinical context to be nonresponsive.

Eligible applicants include U.S.-based nonprofit research organizations, for-profit research organizations, universities and colleges, hospitals and healthcare systems, laboratories and manufacturers, and units of state, local, or federal government. Foreign organizations and non-domestic components of U.S. organizations may apply if there is demonstrable benefit to the U.S. healthcare system and the essential scientific needs will be met by conducting the study outside the United States or having the study conducted by non-US research organizations, U.S. efforts in the area of patient-centered research can be clearly shown, and the engagement plans include U.S. patients and stakeholders and are relevant to U.S. healthcare system.

Letters of Intent are due October 1. Upon review, selected applicants will be invited to submit a full proposal by January 14, 2019.

See the Patient-Centered Outcomes Research Institute website for complete program guidelines and application information.


Deadline: September 27, 2019